Ablation of cerebellar Purkinje cells enhances seizure susceptibility and promotes kindling
Together, these findings suggest that PC ablation contributes to heightened seizure susceptibility and seizure severity, highlighting a modulatory role of cerebellar circuits in epilepsy.
Authors
- Zhen Xiong (ORCID: https://orcid.org/0000-0001-6685-9676)
- Yuxian Zhang (ORCID: https://orcid.org/0000-0002-3926-8317)
- Kexian Li
- Junyan He
- Xuemei Wu
- Xin Wang
- Jing Ding
Institutions
- Sun Yat-sen University (CN)
- Fudan University (CN)
- ShanghaiTech University (CN)
- Center for Excellence in Brain Science and Intelligence Technology (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Epilepsia
- Published
- 2026-03-17
- DOI
- https://doi.org/10.1002/epi.70177
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00