Outcomes of alternative therapy in HLA-B* 13:01 positive leprosy patients without dapsone versus standard MDT in negative patients: A comparative effectiveness study
In our study, dapsone-free alternative regimens demonstrated comparable clinical efficacy and safety to standard MDT in MB patients, providing a viable option for HLA-B*13:01 carriers. These findings, limited by the observational design and regimen heterogeneity, warrant further investigation in prospective trials.
Authors
- Tongsheng Chu
- Furen Zhang
- Shujuan Yuan
- Lijiao Yin
- Zhenzhen Wang
- Hong Liu
- Gang Li
- Hong Wang
- Yonghong Wang
- Yang Li
Institutions
- Shandong University (CN)
- Hunan Provincial Center for Disease Control and Prevention (CN)
- Shandong Provincial Institute of Dermatology and Venereology (CN)
- People’s Hospital of Wenshan Prefecture (CN)
- Xinjiang Uygur Autonomous Region Disease Prevention and Control Center (CN)
- Guangxi Science and Technology Department (CN)
- Minzu Normal University of Xingyi (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2026-03-17
- DOI
- https://doi.org/10.1371/journal.pntd.0014114
- Primary Topic
- Drug-Induced Adverse Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00