Prehospital Whole Blood in Traumatic Hemorrhage — a Randomized Controlled Trial
Among participants with life-threatening hemorrhage, prehospital transfusion of 2 units of whole blood was not superior to standard care in reducing the risk of death or massive transfusion within 24 hours. (Funded by NHS Blood and Transplant and others; ISRCTN Registry number, ISRCTN23657907.).
Authors
- Emily Sanderson (ORCID: https://orcid.org/0000-0003-2268-4194)
- Cara Hudson (ORCID: https://orcid.org/0000-0002-5831-5959)
- Grazia Antonacci (ORCID: https://orcid.org/0000-0001-7742-8003)
- Nikki Dallas (ORCID: https://orcid.org/0009-0009-9604-027X)
- Viona Rundell
- L. Courtney Smith (ORCID: https://orcid.org/0000-0001-7099-7852)
- Richard Lyon (ORCID: https://orcid.org/0000-0002-6339-5666)
- Katie Keen
- Joanne Lucas (ORCID: https://orcid.org/0000-0002-3390-9654)
- Rebecca A. Cardigan (ORCID: https://orcid.org/0000-0001-6823-8937)
- Peter Basham
- Laura Silsby (ORCID: https://orcid.org/0009-0004-6477-9815)
- Ed BG Barnard
- Richard Charlewood (ORCID: https://orcid.org/0000-0002-1798-1189)
- Claire Rourke (ORCID: https://orcid.org/0000-0002-7631-9275)
- Jane Davies
- Jason Smith
- Gavin D. Perkins
- Tom Woolley
- Annie Hawton
- Elizabeth Goodwin
- Anne Weaver
- Simon J. Stanworth
- Laura Green
- Brodie Nolan
Institutions
- St. Michael's Hospital (CA)
- NHS Blood and Transplant (GB)
- Queen Mary University of London (GB)
- Barts Health NHS Trust (GB)
- University of Exeter (GB)
- University of Cambridge (GB)
- Royal Navy (GB)
- University of Surrey (GB)
- University of Warwick (GB)
- University of Oxford (GB)
- St Michael’s Hospital (IE)
- Cambridge School (PT)
- Birmingham Research Park (GB)
- Auckland District Health Board (NZ)
- London Ambulance Service NHS Trust (GB)
- St Michaels Hospital (GB)
- University Hospitals Plymouth NHS Trust (GB)
- Imperial College London (GB)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2026-03-17
- DOI
- https://doi.org/10.1056/nejmoa2516043
- Primary Topic
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 0.00