Visible-Light-Driven Radical Amination/Cyclization of Arylethynyl Quinazolinones To Access Sulfonaminated Quinolino[2,1- <i>b</i> ]quinazolines
A visible-light-driven radical amination/cyclization of arylethynyl quinazolin-4(3<i>H</i>)-ones was developed using <i>N</i>-aminopyridinium salts as sulfonamino radical precursors. A series of sulfonaminated quinolino[2,1-<i>b</i>]quinazolines were successfully synthesized under oxidant- and additive-free conditions. The transformation features a broad substrate scope, good to excellent yields, and mild reaction conditions. Notably, the amination-cyclization reaction could proceed smoothly under natural sunlight irradiation.
Authors
- Ji Ma (ORCID: https://orcid.org/0000-0003-4418-2339)
- Pan Zhao (ORCID: https://orcid.org/0000-0003-0719-6010)
- Li Zhang (ORCID: https://orcid.org/0000-0003-1152-8962)
- Liangru Yang
- Qiyang Liu
- Lingbo Qu
- Jinwei Yuan
- Hewen Gao
Institutions
- Henan University of Technology (CN)
- Zhengzhou University (CN)
- Henan Academy of Sciences (CN)
- Tobacco Research Institute (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-03-17
- DOI
- https://doi.org/10.1021/acs.joc.5c03167
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00