Clinical tips to optimize liquid nitrogen spray cryotherapy in esophageal malignancy

Liquid nitrogen spray cryotherapy is an approved modality that has been used to treat esophageal disease for more than 20 years. This versatile tool effectively ablates unwanted tissue; however, its widespread adoption has been limited by procedural complexity limiting technical success. Drawing on the collective experience of the authors, this article provides practical tips to optimize procedure safety, efficiency, and outcomes, with a focus on esophageal malignancy.