Antiresorptive Therapy and Revision Risk After Primary Total Knee Arthroplasty: A Systematic Review and Meta-Analysis
Bisphosphonate therapy after TKA is associated with a lower risk of all-cause revision; however, the certainty of evidence is low, and the findings are limited by substantial heterogeneity. No consistent benefit was observed for aseptic loosening, periprosthetic fracture, or long-term BMD preservation.
Authors
- Matthew Bullock
- Ramesh Chandra Vadapalli
- Aria Darbandi (ORCID: https://orcid.org/0000-0002-9815-0343)
- Liam M. Cleary
- Andrew B. Huffman
- William Stone
- Alexander Burbelo
Institutions
- Marshall University (US)
Publication Details
- Journal
- Arthroplasty Today
- Published
- 2026-03-17
- DOI
- https://doi.org/10.1016/j.artd.2026.101991
- Primary Topic
- Total Knee Arthroplasty Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00