Safety and neuromodulation effect of transcranial focused ultrasound for motor recovery in patients with subacute stroke

tFUS was safe and well tolerated in subacute stroke patients, with only minor transient AEs and no evidence of structural or neuropsychological harm. tFUS demonstrated potential to enhance upper limb motor recovery and functional outcomes. Although exploratory analyses suggested trends toward cortical excitability changes, these findings were not statistically significant and require confirmation in larger controlled trials.