Visible-Light-Driven ( <i>E</i> )-β-Trifluoromethylation of Enamides via <i>In Situ</i> Generated Sulfur(VI) Photosensitizers

We report an autoinductive, visible-light-mediated (<i>E</i>)-β-trifluoromethylation of enamides using sodium trifluoromethanesulfinate. This protocol eliminates exogenous catalysts by leveraging an <i>in situ</i> generated pentacoordinate sulfur(VI) species as the photosensitizer. Characterized by mild conditions and broad substrate compatibility, the method exhibits promising scalability, as evidenced by a gram-scale continuous-flow synthesis. This oxidant- and catalyst-free strategy provides a robust, scalable paradigm for accessing valuable trifluoromethylated building blocks.