Circulating gut microbial metabolites and risk of coronary heart disease: A prospective multi-stage metabolomics study
We identified and validated circulating gut microbial metabolites associated with incident CHD across diverse populations. Our findings offer novel epidemiological evidence on the importance of gut microbial metabolism in CHD development and highlight specific metabolites to prioritize for mechanistic investigation, biomarker validation, and therapeutic development.
Authors
- Rui Pinto (ORCID: https://orcid.org/0000-0002-8527-4873)
- Danxia Yu
- Loren Lipworth
- Deepak Ramchandra Gupta
- Ioanna Tzoulaki
- David M. Herrington
- Yulu Zheng
- Bing Yu
- Jae Jeong Yang
- Hui Cai
- Xiao-Ou Shu (ORCID: https://orcid.org/0000-0002-0711-8314)
- Ngoc Quynh H. Nguyen
- Wei Zheng
- Qiuyin Cai
Institutions
- University of Florida Health (US)
- University of Texas Health Science Center at Dallas (US)
- Wake Forest University (US)
- Imperial College London (GB)
- Vanderbilt University Medical Center (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- PLoS Medicine
- Published
- 2026-03-17
- DOI
- https://doi.org/10.1371/journal.pmed.1004750
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00