MTHFD2 modulates neural stem cell proliferation and apoptosis after intracerebral hemorrhage by regulating mitochondrial NADPH homeostasis
Our findings identify MTHFD2 as a key metabolic regulator supporting NSC adaptation to ICH through NADPH-dependent mitochondrial mechanisms. Targeting mitochondrial redox metabolism may provide a potential strategy for preserving NSC function and improving cognitive recovery after ICH.
Authors
- Fengzhen Cui (ORCID: https://orcid.org/0000-0002-4014-264X)
- Yuxiao Ma
- C. K. Xu (ORCID: https://orcid.org/0000-0002-1588-6700)
- Yongtao Zheng (ORCID: https://orcid.org/0000-0002-4590-8720)
- Qingfang Sun (ORCID: https://orcid.org/0000-0003-2691-476X)
- Liwen Bian
- Yikui Liu
- Aoqian Xu
- Qixiang Zhang
- Baofeng Wang
- Yuhao Sun
Institutions
- Guangdong Medical College (CN)
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2026-03-17
- DOI
- https://doi.org/10.1186/s12967-026-07961-1
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00