Differences in mRNA expression of neuroinflammation‐related genes in the temporal lobe of patients with drug‐resistant focal epilepsy
Given the cross-sectional study design, causality cannot be determined. However, this study suggests that proinflammatory mechanisms may play a role in the pathogenesis of the ongoing epileptic state in DRTLE. In particular, complement, inflammasome, and microglial/mononuclear cell-mediated inflammatory processes had the most significant elevations in mRNA, while B and T cell associated mRNA were less altered.
Authors
- Matthew Drill (ORCID: https://orcid.org/0000-0001-7946-1309)
- Michael A. Christie
- Mastura Monif (ORCID: https://orcid.org/0000-0001-6404-9768)
- Catriona McLean (ORCID: https://orcid.org/0000-0002-0302-5727)
- Paul G. Sanfilippo (ORCID: https://orcid.org/0000-0002-1778-9154)
- Tracie H. L. Tan
- Patrick Kwan
- Piero Perucca
- Terence J. O'Brien
Institutions
- The Royal Melbourne Hospital (AU)
- The University of Melbourne (AU)
- Walter and Eliza Hall Institute of Medical Research (AU)
- Florey Institute of Neuroscience and Mental Health (AU)
- The Alfred Hospital (AU)
- Austin Health (AU)
- Monash University (AU)
Publication Details
- Journal
- Epileptic Disorders
- Published
- 2026-03-17
- DOI
- https://doi.org/10.1002/epd2.70220
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00