CD8⁺ T cells induce interstrand crosslinking-associated DNA damage in neurons
Results indicate that CD8 <sup>+</sup> T cells induce interstrand crosslinking-like DNA damage in neurons independent of antigen-specificity in a mouse model of viral infection, <i>in vitro</i> primary cell culture system, and human neurologic diseases. These findings provide insight on the mechanistic connection between neuroinflammation and neurologic dysfunction.
Authors
- Britanie M. Blackhurst
- Autumn E. Tucker
- Katie L. Reagin
- Kristen E. Funk (ORCID: https://orcid.org/0000-0002-1912-1430)
- Bree Kurtz
- Emily Kretchmer
- Aayush Bhatt
Institutions
- University of North Carolina at Charlotte (US)
- University of Central Florida (US)
- Florida College (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-03-17
- DOI
- https://doi.org/10.64898/2026.03.14.711737
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00