Modified Gengnianchun Formula Outperforms Androgens in Treating Chronic Stress-Induced Diminished Ovarian Reserve: An Animal Study

Chronic stress-induced hypercortisolism causes diminished ovarian reserve (DOR), contributing to infertility and miscarriage. Androgen supplementation is an emerging therapeutic approach for DOR. The traditional Chinese herbal decoction modified Gengnianchun formula (MGNC) has shown clinical efficacy in treating DOR. This study aimed to compare the effectiveness of MGNC with that of androgens in a stress-induced DOR mouse model.

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Publication Details

Journal
Future Integrative Medicine
Published
2026-03-17
DOI
https://doi.org/10.14218/fim.2025.00047
Primary Topic
Menopause: Health Impacts and Treatments
Type
article
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article

Modified Gengnianchun Formula Outperforms Androgens in Treating Chronic Stress-Induced Diminished Ovarian Reserve: An Animal Study

Jianqin Huang, Li Gao, Hongna Gao, Jun Li et al.
Future Integrative Medicine
Menopause: Health Impacts and Treatments
article

Modified Gengnianchun Formula Outperforms Androgens in Treating Chronic Stress-Induced Diminished Ovarian Reserve: An Animal Study

Jianqin Huang, Li Gao, Hongna Gao, Jun Li, Yanqiu Rao, Wenjun Wang
article en

Abstract

Chronic stress-induced hypercortisolism causes diminished ovarian reserve (DOR), contributing to infertility and miscarriage. Androgen supplementation is an emerging therapeutic approach for DOR. The traditional Chinese herbal decoction modified Gengnianchun formula (MGNC) has shown clinical efficacy in treating DOR. This study aimed to compare the effectiveness of MGNC with that of androgens in a stress-induced DOR mouse model.

Future Integrative MedicineVol. 000(000)
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Openalex Percentile: Top 20%
Menopause: Health Impacts and Treatments
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