Phase III meta-analysis of first-line chemo-immunotherapy in ES-SCLC: Survival benefit without detectable class-level differences

Adding a PD-1/PD-L1 inhibitor to platinum-etoposide in first-line ES-SCLC provides a consistent overall survival benefit, with no statistically detectable differences between PD-1 and PD-L1 inhibitor classes. This finding should be interpreted as absence of detectable class-level divergence rather than pharmacologic equivalence.

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Publication Details

Journal
Lung Cancer
Published
2026-03-17
DOI
https://doi.org/10.1016/j.lungcan.2026.109376
Primary Topic
Lung Cancer Research Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Phase III meta-analysis of first-line chemo-immunotherapy in ES-SCLC: Survival benefit without detectable class-level differences

D. Campana, A.Di Odoardo, A. Zappi, M.G. Formelli et al.
Lung Cancer
Lung Cancer Research Studies
article

Phase III meta-analysis of first-line chemo-immunotherapy in ES-SCLC: Survival benefit without detectable class-level differences

D. Campana, A.Di Odoardo, A. Zappi, M.G. Formelli, E. Andrini, G. Lamberti
article en

Abstract

Adding a PD-1/PD-L1 inhibitor to platinum-etoposide in first-line ES-SCLC provides a consistent overall survival benefit, with no statistically detectable differences between PD-1 and PD-L1 inhibitor classes. This finding should be interpreted as absence of detectable class-level divergence rather than pharmacologic equivalence.

Lung CancerVol. 215
University of Bologna (IT)
Zero hunger
Openalex Percentile: Top 18%
Lung Cancer Research Studies
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