Asymmetric Conjugate Addition of Thiophene Derivative to Nitrostyrenes Using Thiourea Organocatalysts
The asymmetric α-regioselective conjugate addition of 2-thienylacetones to nitrostyrenes was achieved using a tertiary amine-thiourea organocatalyst, affording the α-addition products in high yields with excellent stereoselectivities. This study provides the first demonstration of an asymmetric α-regioselective conjugate addition of 2-thienylacetones to nitroalkenes.
Authors
- Takashi Yamanoi (ORCID: https://orcid.org/0000-0001-5028-2534)
- Kosuke Nakashima (ORCID: https://orcid.org/0000-0001-9323-3521)
- Hiroshi Akutsu
- Tsuyoshi Miura (ORCID: https://orcid.org/0000-0003-1216-4507)
- Taro Koda
- Akihiro Yoshida (ORCID: https://orcid.org/0000-0001-7224-6550)
- Shin-ichi Hirashima
- Mitsuaki Suzuki
Institutions
- Tokyo University of Pharmacy and Life Sciences (JP)
- Josai University (JP)
Publication Details
- Journal
- Chemical and Pharmaceutical Bulletin
- Published
- 2026-03-17
- DOI
- https://doi.org/10.1248/cpb.c25-00802
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00