Sphingosine-1-phosphate – sphinganine-1-phosphate Imbalance Drives Airway Hyperreactivity
An imbalance between sphingosine-1-phosphate and sphinganine-1-phosphate links the asthma risk locus 17q21 to airway hyperreactivity and reveals sphingolipid metabolism as a potential therapeutic target.
Authors
- Jose Perez-Zoghbi
- Andrea Heras Barros
- Tilla S. Worgall (ORCID: https://orcid.org/0000-0002-0587-5223)
- Stefan Worgall (ORCID: https://orcid.org/0000-0003-3716-2890)
- Sarah Brown
Institutions
- Cornell University (US)
- Columbia University Irving Medical Center (US)
- Children's Cancer and Blood Foundation (US)
- Weill Cornell Medicine (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-03-17
- DOI
- https://doi.org/10.64898/2026.03.15.26348448
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00