Clinical Manifestations of Primary CNS T-Cell Lymphoma
Although PCNSTL is exceptionally rare, we identified distinct neuroimaging patterns showing highly aggressive features on MRI but hypometabolic PET imaging, which may assist in identifying future PCNSTL cases. Despite the limited cohort size, our findings suggest that MTX-based chemotherapy with ASCT may translate into favorable outcome. We report on an ALK1-positive PCNSTL case with sustained complete remission after targeted therapy with lorlatinib.
Authors
- Robert Forbrig (ORCID: https://orcid.org/0000-0002-1054-1463)
- E S Conner
- Benjamin Englert (ORCID: https://orcid.org/0000-0002-1769-5393)
- Leon D. Kaulen (ORCID: https://orcid.org/0000-0002-5937-3376)
- Andreas Straube (ORCID: https://orcid.org/0000-0002-1695-1666)
- Nathalie L. Albert (ORCID: https://orcid.org/0000-0003-0953-7624)
- Felix Hinz (ORCID: https://orcid.org/0009-0004-6394-1999)
- Veit M. Stoecklein (ORCID: https://orcid.org/0000-0001-6206-0621)
- Felix Ehret (ORCID: https://orcid.org/0000-0001-6177-1755)
- Jonas Reis (ORCID: https://orcid.org/0000-0001-8932-2265)
- Florian Ringel (ORCID: https://orcid.org/0000-0003-3132-7543)
- Georgios Gakis (ORCID: https://orcid.org/0000-0002-7339-4659)
- Katharina Müller (ORCID: https://orcid.org/0000-0001-7098-4744)
- Benjamin-Leon Traub
- Florian Schoeberl
- Maria Martinez-Lage
- M Subklewe
- P Harter
- Louisa Daniela Von Baumgarten
- Jorg Dietrich
- Martin Dreyling
- Martina Rudelius
- Oliver Weigert
- Philipp Karschnia
Institutions
- Harvard University (US)
- German Cancer Research Center (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- LMU Klinikum (DE)
- Humboldt-Universität zu Berlin (DE)
- Massachusetts General Hospital (US)
- German Cancer Society (DE)
- German Centre for Cardiovascular Research (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Neurology
- Published
- 2026-03-17
- DOI
- https://doi.org/10.1212/wnl.0000000000214744
- Primary Topic
- CNS Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00