456P NK cell heterogeneity is associated with chemoimmunotherapy response in small cell lung cancer patients
SLFN11>1 LCNEC a worse overall survival (OS) (p=0.050) was observed.In SCLC, SLFN11 exp median value was associated with improved OS (13.9 vs 6.8 months; HR=0.48, 95%CI 0.26-0.90,p=0.020).Conclusions: SLFN11 exp in lung NENs is higher in SCLC>LCNEC>TC/AC, in line with its correlation with Ki67 and reflecting its association with proliferative stress.SLFN11 exp was mainly associated with ASCL1 exp in all lung NEN subtypes.While correlating with survival in SCLC, its role in TC/AC and LCNEC remains to be defined.
Authors
- Floriana Morgillo (ORCID: https://orcid.org/0000-0002-9167-323X)
- Virginia Tirino (ORCID: https://orcid.org/0000-0003-2731-5718)
- Simona Sivori (ORCID: https://orcid.org/0000-0003-1279-1172)
- Giuseppe Viscardi (ORCID: https://orcid.org/0000-0003-4473-9387)
- Giuseppe Ercolano (ORCID: https://orcid.org/0000-0001-6026-2588)
- Federica Papaccio (ORCID: https://orcid.org/0000-0002-0302-8696)
- CM Della Corte
- Fabiana Vitiello (ORCID: https://orcid.org/0009-0007-2984-4257)
- Caterina De Rosa (ORCID: https://orcid.org/0000-0001-6540-0708)
- Luisa Amato (ORCID: https://orcid.org/0009-0005-6511-8071)
- Filippo Sepe
- S. Capaldo
- F. Somma
- F. Ciardiello
- F. De Vita
- A. Servetto
- M. Gilli
- E. Mercenaro
Institutions
- University of Salerno (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- Azienda Ospedaliera Universitaria Università degli Studi della Campania Luigi Vanvitelli (IT)
- Ospedale Monaldi (IT)
- University of Naples Federico II (IT)
- University of Genoa (IT)
Publication Details
- Journal
- ESMO Open
- Published
- 2026-03-17
- DOI
- https://doi.org/10.1016/j.esmoop.2026.106770
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00