Reduced Macular Pigment Optical Volume Is Linked to High-Risk OCT Biomarkers and Lower Contrast Sensitivity Function in iAMD
MPOV was significantly associated with high-risk OCT biomarkers and qCSF-derived CS metrics in iAMD, highlighting its potential role as a biomarker of structural integrity and functional impairment not captured by standard VA testing.
Authors
- Archana Nigalye (ORCID: https://orcid.org/0000-0003-1468-7766)
- Augustine Bannerman
- Isabella Stettler
- Ioanna Ploumi (ORCID: https://orcid.org/0000-0001-8475-3170)
- Tomas A. Cort (ORCID: https://orcid.org/0009-0004-8728-7047)
- Filippos Vingopoulos (ORCID: https://orcid.org/0000-0003-3778-5473)
- XINYI DING
- Kayla N. Nodecker
- Hanna Choi
- Ying Zhu
- Chong Chen
- John B. Miller
- Selin Gumustop
- Joan W. Miller
- Deeba Husain
- Demetrios G. Vavvas
- Shivesh Shah
- Francesco Romano
- Inês Laíns
Institutions
- Massachusetts Eye and Ear Infirmary (US)
- Harvard University (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-03-17
- DOI
- https://doi.org/10.1167/iovs.67.3.36
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00