Conventionally Fractionated Radiotherapy (CFRT) Versus Stereotactic Body Radiotherapy (SBRT) for Locally Advanced Pancreatic Cancer: A Systematic Review and Meta-Analysis of Comparative Studies

SBRT appears to achieve survival outcomes comparable to CFRT with a favorable acute toxicity profile in patients with LAPC. Nevertheless, the current evidence is limited by retrospective designs and heterogeneity, highlighting the need for prospective randomized trials to define the role of SBRT in this setting.

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Publication Details

Journal
Cancers
Published
2026-03-17
DOI
https://doi.org/10.3390/cancers18060971
Primary Topic
Pancreatic and Hepatic Oncology Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Conventionally Fractionated Radiotherapy (CFRT) Versus Stereotactic Body Radiotherapy (SBRT) for Locally Advanced Pancreatic Cancer: A Systematic Review and Meta-Analysis of Comparative Studies

Nunziata D’Abbiero, Giovanna Mantello, Pierfrancesco Franco, Domenico Genovesi et al.
Cancers
Pancreatic and Hepatic Oncology Research
article

Conventionally Fractionated Radiotherapy (CFRT) Versus Stereotactic Body Radiotherapy (SBRT) for Locally Advanced Pancreatic Cancer: A Systematic Review and Meta-Analysis of Comparative Studies

Nunziata D’Abbiero, Giovanna Mantello, Pierfrancesco Franco, Domenico Genovesi, G. Capezzali, R.M. Niespolo, Nicola Simoni, Marco Lupattelli, Marcin Miszczyk, Fabio Matrone, Giampaolo Montesi, M. La Macchia, Luca Nicosia, Michele Fiore, Francesca De Felice, Francesco Cellini
article en

Abstract

SBRT appears to achieve survival outcomes comparable to CFRT with a favorable acute toxicity profile in patients with LAPC. Nevertheless, the current evidence is limited by retrospective designs and heterogeneity, highlighting the need for prospective randomized trials to define the role of SBRT in this setting.

CancersVol. 18(6)
Università Cattolica del Sacro Cuore (IT), Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT), University of Parma (IT), Università Campus Bio-Medico (IT), University of Perugia (IT), Policlinico Umberto I (IT), Agostino Gemelli University Polyclinic (IT), University of Chieti-Pescara (IT), Comprehensive Cancer Center Vienna (AT), Ospedale Sacro Cuore Don Calabria (IT), Azienda Ospedaliero Universitaria Ospedali Riuniti (IT), Azienda Ospedaliera San Gerardo (IT), Ospedali Riuniti Marche Nord (IT), Azienda Ospedaliero Universitaria Maggiore della Carita (IT), Centro di Riferimento Oncologico (IT), Campus Bio Medico University Hospital (IT), Azienda Ospedaliera Ospedale Maggiore (IT), WSB University (PL), Istituti di Ricovero e Cura a Carattere Scientifico (IT), Medical University of Vienna (AT), Sapienza University of Rome (IT)
Good health and well-being
Openalex Percentile: Top 18%
Pancreatic and Hepatic Oncology Research
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