Impact of voluntary exercise on obesity-induced brain pathology: Insights from a multimodal approach in male Ldlr-/-.Leiden mice
Voluntary exercise offered partial mitigation of HFD-induced damage, with indications of less severe microgliosis, microvascular remodeling and axonal disruption. Pathology-MRI co-registration revealed associations between neuroinflammation and diffusion metrics, supporting multimodal approaches to interpret MRI and guide development of optimal targeted interventions for obesity-related brain pathology.
Authors
- Maximilian Wiesmann (ORCID: https://orcid.org/0000-0002-1412-398X)
- Martine Morrison
- Klara J. Lohkamp
- Amanda J. Kiliaan (ORCID: https://orcid.org/0000-0002-2158-6210)
- Robert Kleemann (ORCID: https://orcid.org/0000-0002-1350-0149)
- Anita M. van den Hoek (ORCID: https://orcid.org/0000-0002-7077-8446)
- Bram Geenen (ORCID: https://orcid.org/0000-0001-7838-3097)
- Viviènne Verweij
- Gemma Solé-Guardia
- Xiaoxue Liang
Institutions
- Radboud University Nijmegen (NL)
- Netherlands Organisation for Applied Scientific Research (NL)
- Radboud University Medical Center (NL)
- Radboud Institute for Molecular Life Sciences (NL)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2026-03-17
- DOI
- https://doi.org/10.1016/j.bbi.2026.106539
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00