507P Biomarker assessment in ROS1+ NSCLC
Mendelian randomization also suggested a causal role for specific proteins in lung cancer development. Conclusions:Our findings establish that lung cancer evolves through a dynamic sequence of protein changes.This provides a new model for understanding prediagnostic disease, and our 9-protein signature is a powerful tool for precision screening to identify individuals with active disease progression.Legal entity responsible for the study: The authors.
Authors
- Federico Cappuzzo (ORCID: https://orcid.org/0000-0002-6295-6767)
- Gabriele Minuti (ORCID: https://orcid.org/0000-0003-2363-0446)
- Corrado Orciuolo
- Andrea Torchia (ORCID: https://orcid.org/0000-0002-4020-6893)
- Maurizio Fanciulli (ORCID: https://orcid.org/0000-0002-5281-4191)
- Lorenza Maria Landi (ORCID: https://orcid.org/0000-0003-2604-6595)
- M. Giammaruco
- R. Mencarini
- F. Larocca
- S. Scalera
Institutions
- Tumori Foundation (US)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Instituto Nazionale Tumori Regina Elena (IT)
Publication Details
- Journal
- ESMO Open
- Published
- 2026-03-17
- DOI
- https://doi.org/10.1016/j.esmoop.2026.106822
- Primary Topic
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00