Acid stress modulates metabolo-inflammatory pathways in oral epithelial cells
Acute acid exposure reduces survival of OECsA subpopulation of OECs is resistant to acid-mediated cell loss and undergo morphometric changes consistent with epithelial-mesenchymal transitionConcurrent acid stress and TLR stimulation modulates transcription of immune and metabolic genes in OECsAcid stress increases TGF-β1 protein production of OECs following TLR agonist stimulation.
Authors
- Christina Graves (ORCID: https://orcid.org/0000-0002-7387-2462)
- Angela Chen (ORCID: https://orcid.org/0000-0003-0214-8482)
- Cameron T. Dixon
- Karen Zhu
- Adam Lietzan
Institutions
- University of North Carolina at Chapel Hill (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-03-17
- DOI
- https://doi.org/10.64898/2026.03.16.711383
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00