COX5A induces M2 macrophage polarization in chronic rhinosinusitis with nasal polyps through ROS generation
Our research highlights the crucial role of mitochondrial dysfunction, particularly through COX5A-mediated reactive oxygen species (ROS) generation, in promoting the polarization of M2 macrophages and the progression of CRSwNP. These findings emphasize the potential for targeting mitochondrial-immune crosstalk as an effective therapeutic strategy, thereby opening new avenues for addressing CRSwNP.
Authors
- Jia‐Yi Wang (ORCID: https://orcid.org/0000-0002-9106-3351)
- Bowen Zheng (ORCID: https://orcid.org/0009-0003-0304-1553)
- Y. T. Gu (ORCID: https://orcid.org/0009-0005-8547-353X)
- Dayu Guan
- Panhui Xiong
- Yucheng Yang
- Xuemei Chen
- Yang Shen
- Yuan Chen
- Tao Lu
Institutions
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Inflammation Research
- Published
- 2026-03-17
- DOI
- https://doi.org/10.1007/s00011-025-02181-7
- Primary Topic
- Sinusitis and nasal conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00