Tuberculous lymphadenitis presenting with Coombs-negative hemolytic anemia, vasculitic rash: A rare association

Tuberculosis (TB) is a widespread infectious disease that primarily affects the lungs but can manifest in extrapulmonary forms, such as lymphadenitis. The occurrence of severe anemia, direct Coombs test-negative hemolysis, and vasculitic rash in a patient with tuberculous lymphadenitis is an uncommon and challenging clinical scenario. We report the case of a 21-year-old male presenting with scattered petechiae, lower limb swelling, and fatigue, ultimately diagnosed with tuberculous lymphadenitis. This case report highlights the importance of considering TB in atypical presentations to ensure timely diagnosis and treatment.

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Publication Details

Journal
Indian Journal of Medical Sciences
Published
2026-03-17
DOI
https://doi.org/10.25259/ijms_94_2025
Primary Topic
Vasculitis and related conditions
Type
article
Field-Weighted Citation Impact
0.00
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article

Tuberculous lymphadenitis presenting with Coombs-negative hemolytic anemia, vasculitic rash: A rare association

Prudvi Tarun Betha, Angela Philips
Indian Journal of Medical Sciences
Vasculitis and related conditions
article

Tuberculous lymphadenitis presenting with Coombs-negative hemolytic anemia, vasculitic rash: A rare association

Prudvi Tarun Betha, Angela Philips
article en

Abstract

Tuberculosis (TB) is a widespread infectious disease that primarily affects the lungs but can manifest in extrapulmonary forms, such as lymphadenitis. The occurrence of severe anemia, direct Coombs test-negative hemolysis, and vasculitic rash in a patient with tuberculous lymphadenitis is an uncommon and challenging clinical scenario. We report the case of a 21-year-old male presenting with scattered petechiae, lower limb swelling, and fatigue, ultimately diagnosed with tuberculous lymphadenitis. This case report highlights the importance of considering TB in atypical presentations to ensure timely diagnosis and treatment.

Indian Journal of Medical SciencesVol. 78
Himalayan University (IN)
Good health and well-being
Openalex Percentile: Top 19%
Vasculitis and related conditions
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