Characterization and Management of Cytokine Release Syndrome From the MonumenTAL-1 Study of Talquetamab in Patients With Relapsed/Refractory Multiple Myeloma

[Introduction] Cytokine release syndrome (CRS) is a common adverse event associated with T-cell redirection therapies (TCRT), including talquetamab, the first GPRC5D × CD3 bispecific antibody approved for relapsed/refractory multiple myeloma (RRMM). We describe CRS with talquetamab and implications for clinical practice.

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Publication Details

Journal
DIGITAL.CSIC (Spanish National Research Council (CSIC))
Published
2025-10-01
DOI
https://doi.org/10.1002/cam4.71276digital
Primary Topic
Multiple Myeloma Research and Treatments
Type
article
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article

Characterization and Management of Cytokine Release Syndrome From the MonumenTAL-1 Study of Talquetamab in Patients With Relapsed/Refractory Multiple Myeloma

Sheri Skerget, Brandi Hilder, Thomas Renaud, Tara Masterson et al.
DIGITAL.CSIC (Spanish National Research Council (CSIC))
Multiple Myeloma Research and Treatments
article

Characterization and Management of Cytokine Release Syndrome From the MonumenTAL-1 Study of Talquetamab in Patients With Relapsed/Refractory Multiple Myeloma

Sheri Skerget, Brandi Hilder, Thomas Renaud, Tara Masterson, Jaszianne Tolbert, Raluca Verona, Christoph Heuck, Brea Lipe, Jue Gong, Indrajeet Singh, Leo Rasche, Ajai Chari, Amrita Krishnan, Niels W. C. J. van de Donk, Thomas Martin, Jing Christine Ye, Deeksha Vishwamitra, Rakesh Popat, M. Damiette Smit, César Rodríguez, Carolina Schinke, Michela Campagna, Maria Victoria Mateos
article en

Abstract

[Introduction] Cytokine release syndrome (CRS) is a common adverse event associated with T-cell redirection therapies (TCRT), including talquetamab, the first GPRC5D × CD3 bispecific antibody approved for relapsed/refractory multiple myeloma (RRMM). We describe CRS with talquetamab and implications for clinical practice.

DIGITAL.CSIC (Spanish National Research Council (CSIC))
Good health and well-being
Openalex Percentile: Top 20%
Multiple Myeloma Research and Treatments
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Characterization and Management of Cytokine Release Syndrome From the MonumenTAL-1 Study of Talquetamab in Patients With Relapsed/Refractory Multiple Myeloma — Sheri Skerget, Brandi Hilder, et al. · DIGITAL.CSIC (Spanish National Research Council (CSIC)) (2025) | TGRS Research Map | TGRS