Hyperparathyroidism-Jaw Tumor Syndrome: A Rare Case

Hyperparathyroidism-jaw tumor (HPT-JT) syndrome is an uncommon autosomal dominant disorder associated with primary hyperparathyroidism due to parathyroid adenomas and ossifying jaw tumors. We present the case of a 31-year-old male who was incidentally diagnosed with severe parathyroid hormone-dependent hypercalcemia following a traumatic upper limb fracture. Subsequent evaluation confirmed the diagnosis of HPT-JT syndrome. Early recognition, prompt surgical management, and genetic confirmation are essential to ensure appropriate treatment and prevent long-term complications.

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Publication Details

Journal
Cureus
Published
2026-03-16
DOI
https://doi.org/10.7759/cureus.105352
Primary Topic
Parathyroid Disorders and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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Hyperparathyroidism-Jaw Tumor Syndrome: A Rare Case

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Hyperparathyroidism-Jaw Tumor Syndrome: A Rare Case

Adlyne Reena Asirvatham, Dorai Arun Kumar, Sandhya Sundaram, Shriraam Mahadevan, Kunal Gupta, Narayanan Cunnigaiper
article en

Abstract

Hyperparathyroidism-jaw tumor (HPT-JT) syndrome is an uncommon autosomal dominant disorder associated with primary hyperparathyroidism due to parathyroid adenomas and ossifying jaw tumors. We present the case of a 31-year-old male who was incidentally diagnosed with severe parathyroid hormone-dependent hypercalcemia following a traumatic upper limb fracture. Subsequent evaluation confirmed the diagnosis of HPT-JT syndrome. Early recognition, prompt surgical management, and genetic confirmation are essential to ensure appropriate treatment and prevent long-term complications.

Cureus
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Openalex Percentile: Top 29%
Parathyroid Disorders and Treatments
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