Investigating Placebos and Controls Used in Large Language Model–Based Chatbot Intervention Trials: Protocol for a Methodological Review

Authors

Marco Annoni (ORCID: https://orcid.org/0000-0003-3259-1856)
Moa Pontén (ORCID: https://orcid.org/0000-0002-2407-0412)
Vanda Faria (ORCID: https://orcid.org/0000-0002-6781-8398)
Leo Druart
John Torous
Charlotte Blease

Institutions

Uppsala University (SE)
Beth Israel Deaconess Medical Center (US)
Brown University (US)
Karolinska Institutet (SE)
Stockholm Health Care Services (SE)
Center for Pain and the Brain (US)
National Research Council (IT)
University Hospital Carl Gustav Carus (DE)

Publication Details

Journal: JMIR Research Protocols
Published: 2026-03-17
DOI: https://doi.org/10.2196/90507
Primary Topic: Digital Mental Health Interventions
Type: article
Field-Weighted Citation Impact: 0.00

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article

Investigating Placebos and Controls Used in Large Language Model–Based Chatbot Intervention Trials: Protocol for a Methodological Review

Marco Annoni, Moa Pontén, Vanda Faria, Leo Druart et al.

Mar 17, 2026

JMIR Research Protocols

Digital Mental Health Interventions

article

Investigating Placebos and Controls Used in Large Language Model–Based Chatbot Intervention Trials: Protocol for a Methodological Review

Marco Annoni, Moa Pontén, Vanda Faria, Leo Druart, John Torous, Charlotte Blease

March 17, 2026article en

Abstract

No abstract available for this paper.

JMIR Research ProtocolsVol. 15

Uppsala University (SE), Beth Israel Deaconess Medical Center (US), Brown University (US), Karolinska Institutet (SE), Stockholm Health Care Services (SE), Center for Pain and the Brain (US), National Research Council (IT), University Hospital Carl Gustav Carus (DE)

Openalex Percentile: Top 19%

Digital Mental Health Interventions

DOI Open Access PDF OpenAlex

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