Nobiletin from Xiaoyu Xiezhuo Decoction: Restoring Mitochondrial Dynamics and Alleviating Renal Ischemia-Reperfusion Injury via M1 Macrophage Modulation

By preventing M1 macrophage polarization, lowering inflammation, and reestablishing mitochondrial homeostasis in renal tubular epithelial cells, this study showed that NOB has renoprotective benefits. These results provided fresh perspectives on NOB's potential as a treatment for renal IRI.

Authors

Publication Details

Journal
Kidney & Blood Pressure Research
Published
2026-03-17
DOI
https://doi.org/10.1159/000551502
Primary Topic
Bioactive Compounds in Plants
Type
article
Field-Weighted Citation Impact
0.00
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article

Nobiletin from Xiaoyu Xiezhuo Decoction: Restoring Mitochondrial Dynamics and Alleviating Renal Ischemia-Reperfusion Injury via M1 Macrophage Modulation

Zhouzhou Dong, Yiru Weng, Jing Huang, Yuan Yuan et al.
Kidney & Blood Pressure Research
Bioactive Compounds in Plants
article

Nobiletin from Xiaoyu Xiezhuo Decoction: Restoring Mitochondrial Dynamics and Alleviating Renal Ischemia-Reperfusion Injury via M1 Macrophage Modulation

Zhouzhou Dong, Yiru Weng, Jing Huang, Yuan Yuan, Yinchao Zhou, Zhibo Weng
article en

Abstract

By preventing M1 macrophage polarization, lowering inflammation, and reestablishing mitochondrial homeostasis in renal tubular epithelial cells, this study showed that NOB has renoprotective benefits. These results provided fresh perspectives on NOB's potential as a treatment for renal IRI.

Kidney & Blood Pressure Research
Openalex Percentile: Top 19%
Bioactive Compounds in Plants
DOIOpen Access PDFOpenAlex
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Nobiletin from Xiaoyu Xiezhuo Decoction: Restoring Mitochondrial Dynamics and Alleviating Renal Ischemia-Reperfusion Injury via M1 Macrophage Modulation — Zhouzhou Dong, Yiru Weng, et al. · Kidney & Blood Pressure Research (2026) | TGRS Research Map | TGRS