Associations of cortisol with Alzheimer’s disease fluid and neuroimaging biomarkers: A systematic review

Findings have been mixed, partly due to differences in cortisol measurement methodologies, including the timing and source of cortisol assessment. More longitudinal studies are needed to determine whether cortisol dysregulation preceded pathological changes related to AD.

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Publication Details

Journal
Frontiers in Neuroendocrinology
Published
2026-03-17
DOI
https://doi.org/10.1016/j.yfrne.2026.101246
Primary Topic
Stress Responses and Cortisol
Type
article
Field-Weighted Citation Impact
0.00
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article

Associations of cortisol with Alzheimer’s disease fluid and neuroimaging biomarkers: A systematic review

Jasper Holleman, Ingemar Kåreholt, Miia Kivipelto, Lefkos Middleton et al.
Frontiers in Neuroendocrinology
Stress Responses and Cortisol
article

Associations of cortisol with Alzheimer’s disease fluid and neuroimaging biomarkers: A systematic review

Jasper Holleman, Ingemar Kåreholt, Miia Kivipelto, Lefkos Middleton, Sima Toopchiani, Alina Solomon, S. Sindi, Chinedu T. Udeh-Momoh, Oliver Robinson
article en

Abstract

Findings have been mixed, partly due to differences in cortisol measurement methodologies, including the timing and source of cortisol assessment. More longitudinal studies are needed to determine whether cortisol dysregulation preceded pathological changes related to AD.

Frontiers in NeuroendocrinologyVol. 81
Karolinska University Hospital (SE), Karolinska Institutet (SE), Imperial College London (GB), Jönköping University (SE)
Good health and well-being
Openalex Percentile: Top 18%
Stress Responses and Cortisol
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