Gut Microbiome Composition and Function, Diet and Clinical Factors in Relation to Fermentable Carbohydrate-Induced Bloating: A Double-Blind, Randomized, Crossover Trial
A higher burden of GI symptoms predicts clinical response to fermentable fibers in functional bloating, while for α-GOS, higher repeated fasting breath H2 is also a predictor. Gut microbiome function and fermentation is associated with functional bloating; however, further investigations are required to draw firm conclusions for the microbial influence in this interplay.ClinicalTrials.gov (Identifier: NCT04802798).
Authors
- Sudarshan Anand Shetty (ORCID: https://orcid.org/0000-0001-7280-9915)
- Matthieu Pichaud (ORCID: https://orcid.org/0000-0002-9089-6693)
- Philippa Gibson
- Aurélie Cotillard (ORCID: https://orcid.org/0009-0004-7409-7703)
- Daniel So (ORCID: https://orcid.org/0000-0002-9560-4469)
- Laurent Quinquis
- Julien Tap (ORCID: https://orcid.org/0000-0001-8998-5413)
- Samantha Morris
- Bridgette Wilson
- M Rossi
- Chris Probert
- Dominic N Farsi
- Rachael Slater
- S. Mark Scott
- Boris Le Nevé
- Kevin Whelan
Institutions
- DSM (Netherlands) (NL)
- University of Liverpool (GB)
- Queen Mary University of London (GB)
- King's College London (GB)
- Danone (Netherlands) (NL)
Publication Details
- Journal
- The American Journal of Gastroenterology
- Published
- 2026-03-17
- DOI
- https://doi.org/10.14309/ajg.0000000000003997
- Primary Topic
- Body Contouring and Surgery
- Type
- article
- Field-Weighted Citation Impact
- 0.00