Occult Nodal Disease in Gallbladder Cancer: An International Multi-institutional Analysis and Preoperative Risk Stratification
OND was present in approximately one-third of clinically node-negative GBC patients undergoing lymphadenectomy. Preoperative jaundice, elevated CA19-9, and elevated SII independently predicted OND and provided simple risk stratification. Incorporating these readily available markers into preoperative assessment may improve risk enrichment for OND and help guide additional staging and treatment sequencing.
Authors
- Kizuki Yuza (ORCID: https://orcid.org/0000-0002-2419-4423)
- Tom Hugh
- Kota Sahara
- Minoru Kitago
- Timothy M. Pawlik
- Yutaka Endo
- Jun Kawashima
- Yuki Homma
- Itaru Endo
- Federico Aucejo
- Andrea Ruzzenente
- Hugo P. Marques
Institutions
- University of Verona (IT)
- The University of Sydney (AU)
- Cleveland Clinic (US)
- Keio University (JP)
- The Ohio State University Wexner Medical Center (US)
- University of Rochester Medical Center (US)
- Hospital Curry Cabral (PT)
- Yokohama City University (JP)
Publication Details
- Journal
- Annals of Surgical Oncology
- Published
- 2026-03-17
- DOI
- https://doi.org/10.1245/s10434-026-19460-0
- Citations
- 1
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 39.15