Dibutyl phthalate exposure induces thyroid toxicity through follicular cell pyroptosis <i>via</i> the NRF2/KEAP1/NF-κB pathway
DBP induces thyrotoxicity through oxidative stress, inflammation, and pyroptosis, mediated by NRF2/KEAP1 suppression and NF-κB activation. These results provide novel insights into the mechanisms of DBP-induced thyroid damage and highlight potential health risks associated with prolonged exposure.
Authors
- Fangda Fu
- Hongwei Ruan (ORCID: https://orcid.org/0000-0002-6632-0803)
- Keqi Fu
- Huan Luo
- Yuying Chen
- Jiong Yang
- Jieyi Wang
Institutions
- Zhejiang Chinese Medical University (CN)
- Sir Run Run Shaw Hospital (CN)
- Fuyang City People's Hospital (CN)
- CM Hospital (KR)
- Second Affiliated Hospital of Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1080/07853890.2026.2643496
- Primary Topic
- Effects and risks of endocrine disrupting chemicals
- Type
- article
- Field-Weighted Citation Impact
- 0.00