symptom patterns outside the rome iv consensus in eastern and western patients with a disorder of gut-brain interaction
Our study revealed 10 distinct symptom clusters. Some aligned with Rome criteria but other extended beyond its strict anatomical divisions, challenging a key assumption of the Rome classification framework. These results provide novel insight on a multicontinental scale about the complexity of symptom patterns in DGBI and their anatomical relationships .
Authors
- Esther Colomier (ORCID: https://orcid.org/0000-0002-5821-6723)
- Parisa Hajihashemi (ORCID: https://orcid.org/0000-0001-8375-1333)
- Khoo Xin Hui
- Karen Van den Houte (ORCID: https://orcid.org/0000-0003-4910-4639)
- Lieselot Holvoet
- Natasha A. Koloski (ORCID: https://orcid.org/0000-0002-8647-5933)
- Guillaume Gourcerol (ORCID: https://orcid.org/0000-0001-8220-9155)
- Hassan Shahoon
- C. Melchior
- G Holtmann
- Marilia Carabotti (ORCID: https://orcid.org/0000-0001-9984-4630)
- Kewin Tien Ho Siah (ORCID: https://orcid.org/0000-0002-2795-5101)
- Bert Broeders (ORCID: https://orcid.org/0000-0001-6050-8461)
- Sanjiv Mahadeva (ORCID: https://orcid.org/0000-0001-5824-0590)
- Kok-Ann Gwee
- Payman Adibi (ORCID: https://orcid.org/0000-0003-3247-4828)
- Tao Bai (ORCID: https://orcid.org/0000-0002-2522-193X)
- Florencia Carbone
- Peter Liptak
- Takashi Ueda
- Magnus Simrén
- Kee-Huat Chuah
- Michael P. Jones
- Cedric Van de Bruaene
- Bruno Annibale
- Jan Tack
- Peter Banovcin
- Hidekazu Suzuki
- Masaya Sano
- Jinsong Liu
Institutions
- University of North Carolina at Chapel Hill (US)
- Isfahan University of Medical Sciences (IR)
- Tokai University (JP)
- Inserm (FR)
- Wuhan University of Technology (CN)
- Gleneagles Hospital (SG)
- Princess Alexandra Hospital (AU)
- University of Malaya (MY)
- Normandie Université (FR)
- Azienda Ospedaliera Sant'Andrea (IT)
- National University Hospital (SG)
- Centre Hospitalier Universitaire de Rouen (FR)
- Martin University Hospital (SK)
- Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau
- Wuhan University of Science and Technology (CN)
- Université de Rouen Normandie (FR)
- Comenius University Bratislava (SK)
- University of Gothenburg (SE)
- Macquarie University (AU)
- KU Leuven (BE)
Publication Details
- Journal
- The American Journal of Gastroenterology
- Published
- 2026-03-17
- DOI
- https://doi.org/10.14309/ajg.0000000000003996
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00