Clinical complete response as a surrogate for pathological response in bladder cancer: a systematic review and meta‐analysis
Current evidence does not support relying on the current definition of cCR alone, which poorly predicts pCR, to guide treatment decisions. Ongoing trials assessing the combination of MRI plus TURB with urine and/or blood based circulating tumour DNA may help refine cCR evaluation and support the sole introduction of bladder-sparing approaches in patients with MIBC who respond to neoadjuvant systemic therapy.
Authors
- Malte W. Vetterlein (ORCID: https://orcid.org/0000-0001-5987-3883)
- Navid Roessler (ORCID: https://orcid.org/0009-0008-2792-9828)
- P. Karakiewicz
- S. Shariat
- Bernadett Szabados (ORCID: https://orcid.org/0000-0002-8786-0032)
- Jeremy Yuen‐Chun Teoh (ORCID: https://orcid.org/0000-0002-9361-2342)
- Victor M. Schuettfort (ORCID: https://orcid.org/0000-0002-7114-0508)
- Markus von Deimling (ORCID: https://orcid.org/0000-0002-9954-3413)
- Katharina Oberneder
- Alessandro Dematteis
- Shota Inoue
- Marcin Miszczyk
- Margit Fisch
- Paolo Gontero
- Pawel Rajwa
- Keiichiro Miyajima
Institutions
- Al-Ahliyya Amman University (JO)
- Jikei University School of Medicine (JP)
- University College London Hospitals NHS Foundation Trust (GB)
- Universität Hamburg (DE)
- Okayama University (JP)
- Medical University of Silesia (PL)
- Queen Mary University of London (GB)
- Chinese University of Hong Kong (HK)
- Cornell University (US)
- Charles University (CZ)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Comprehensive Cancer Center Vienna (AT)
- University Medical Center Hamburg-Eppendorf (DE)
- WSB University (PL)
- University College London (GB)
- Université de Montréal (CA)
- Medical University of Vienna (AT)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- British Journal of Urology
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1111/bju.70214
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00