Multi-omics reveals key molecular and cellular features of advanced small cell lung cancers associated with distinct therapeutic opportunities
We showed that methylation of the most common source of tumor tissue in the clinical setting can stratify SCLCs with distinct clinical outcomes and potentially tailored therapeutic options. Methylation can characterize the intrinsic and extrinsic heterogeneity of SCLCs and fuel the discovery of novel therapeutic vulnerabilities to help bridge the gap between research and clinical application to improve care for SCLC patients.
Authors
- David Fielding (ORCID: https://orcid.org/0000-0003-0506-4233)
- Nicola Waddell (ORCID: https://orcid.org/0000-0002-3950-2476)
- Carl Pahoff (ORCID: https://orcid.org/0000-0001-9910-2004)
- Andrew J. Dalley (ORCID: https://orcid.org/0000-0002-8362-6492)
- Vanessa Lakis (ORCID: https://orcid.org/0000-0001-5025-8120)
- Christopher Grainge (ORCID: https://orcid.org/0000-0002-6565-9928)
- Jemma J. Christie (ORCID: https://orcid.org/0000-0003-4478-0494)
- Scott Twaddell (ORCID: https://orcid.org/0009-0009-5529-4556)
- Jonathan Williamson (ORCID: https://orcid.org/0000-0003-4957-3961)
- Shailendra Gune
- John V. Pearson (ORCID: https://orcid.org/0000-0003-0904-4598)
- Lakshmy Nandakumar
- Conrad Leonard (ORCID: https://orcid.org/0000-0002-4131-2065)
- Jung Hwa Son (ORCID: https://orcid.org/0009-0007-6778-9906)
- Daniel Steinfort (ORCID: https://orcid.org/0000-0002-8998-2949)
- Felicity Newell (ORCID: https://orcid.org/0000-0003-0469-2705)
- Lambros T. Koufariotis (ORCID: https://orcid.org/0000-0002-4917-1375)
- Farzad Bashirzadeh
- Kimberley Ryan (ORCID: https://orcid.org/0000-0002-8188-9977)
- Haarika Chittoory (ORCID: https://orcid.org/0000-0003-2793-3196)
- Margaret C. Cummings (ORCID: https://orcid.org/0000-0002-7657-0240)
- Kate Fitzgerald (ORCID: https://orcid.org/0000-0002-1227-2914)
- Jelena Solujic (ORCID: https://orcid.org/0009-0000-5034-693X)
- L. McIntosh
- Kaltin Ferguson
- Michael S. Brown
- David Arnold
- Sunil R. Lakhani
- Katia Nones
- Mahendra Singh
- David Fairbairn
- Oliver Holmes
- Peter T. Simpson
- Matthew Gibney
- Phan Tien Nguyen
- Scott Wood
- Andrew Pattison
Institutions
- Royal Adelaide Hospital (AU)
- The Royal Melbourne Hospital (AU)
- Queensland University of Technology (AU)
- The University of Queensland (AU)
- The University of Melbourne (AU)
- QIMR Berghofer Medical Research Institute (AU)
- Royal Brisbane and Women's Hospital (AU)
- Gold Coast Hospital (AU)
- John Hunter Hospital (AU)
- Liverpool Hospital (AU)
- Sunshine Coast University Hospital (AU)
Publication Details
- Journal
- Genome Medicine
- Published
- 2026-03-17
- DOI
- https://doi.org/10.1186/s13073-026-01624-y
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00