STC2 promotes colorectal cancer progression via c-Myc-mediated glycolysis and the PI3K/AKT/mTOR pathway
These findings highlight STC2 as a key regulator of CRC progression, which regulates c-Myc-driven glycolysis through the PI3K/AKT/mTOR pathway. Targeting STC2 or its downstream metabolic effectors may provide new therapeutic strategies for CRC management.
Authors
- Fangzhou Ye
- Peiyu Qian
- Huanqing Li
- Fan Li
- Li Feng
- Xiaohong Zhang
- Jun Jiang
Institutions
- Fudan University (CN)
- Minhang District Central Hospital (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2026-03-17
- DOI
- https://doi.org/10.1007/s12672-026-04733-7
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00