Electroacupuncture enhances CSPCs proliferation in an FGFR4-mediated manner to ameliorate osteoarthritis-associated pain and cartilage degeneration
Our findings in this study provide valuable insights into the molecular and cellular mechanisms underlying the effects of EA on pain and cartilage degeneration in OA mice. EA may enhance CSPCs' function via the Ca2+/STAT3/FGFR4 signaling pathway in the OA mice model, providing possible novel targets for treating chronic aging-related OA diseases.
Authors
- Lanyue Sheng
- Ban Feng
- Shuai Zhao (ORCID: https://orcid.org/0009-0002-0483-2210)
- Lize Xiong
- Jianxing Song
- Jun Xu
- Guolin Lu
- Liang Zhang
- Jian Wang
- Jiaxin Liu
- Tengfei Li
Institutions
- University of North Carolina at Chapel Hill (US)
- Tongji University (CN)
- Fujian Medical University (CN)
- Fujian Women and Children Hospital (CN)
- Shanghai East Hospital (CN)
- Tang Du Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Chinese Medical Journal
- Published
- 2026-03-17
- DOI
- https://doi.org/10.1097/cm9.0000000000004097
- Primary Topic
- Acupuncture Treatment Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00