The pharmacodynamics of polymyxin B in <i>Acinetobacter baumannii</i> in murine thigh and lung infection models
Whereas polymyxin B treatment had good efficacy in the murine thigh infection model, in the lung infection model its effect was limited. PD targets, with MICs of circulating A. baumannii isolates of ≤2 mg/L, are not reached with a standard human dosing regimen and will probably exceed threshold values for toxicity. These data suggest that the efficacy of polymyxin B as monotherapy for A. baumannii infections is questionable.
Authors
- Sanne van den Berg (ORCID: https://orcid.org/0000-0001-9209-0178)
- Willem A. M. de Jong
- Sebastiaan D. T. Sassen (ORCID: https://orcid.org/0000-0002-4525-638X)
- Michel Pieren (ORCID: https://orcid.org/0000-0001-7896-254X)
- A. F. Muller
- Glenn E. Dale
- Catharina S C Boonman
Institutions
- Erasmus MC (NL)
- Medisch Centrum Haaglanden (NL)
- Allgemeine Gewerbeschule Basel (CH)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2026-03-02
- DOI
- https://doi.org/10.1093/jac/dkag097
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00