Dynamics of Quantiferon-Gold Plus results in a large TB preventive treatment trial across three high-burden HIV/TB countries
QFT-Plus conversions and reversions occurred frequently in PLHIV and did not differ by TPT regimen, or between those who did and did not receive a second course of TPT. The high rate of QFT-positivity, along with the large proportion of conversions despite TPT highlights the complexity of interpreting serial IGRA results in PLHIV in high-transmission scenarios.
Authors
- Belén Saavedra (ORCID: https://orcid.org/0000-0002-4057-0214)
- S.-H. Wang
- Carlos Fernández Escobar
- Gavin Churchyard (ORCID: https://orcid.org/0000-0002-4269-3699)
- LeeAnne Masilela
- Zainab Waggie
- Getnet Yimer
- Neil Alexander Martinson (ORCID: https://orcid.org/0000-0002-0184-5705)
- Violet Chihota
- Kathy Mngadi
- W. Brumskine
- Leonardo Martinez
- Alison D Grant
- Salome Charalambous
- Susan van den Hof
- Katherine Fielding
- Richard Chaisson
- Alberto L Garcia-Basteiro
- Frank Cobelens
- Dinis Nguenha
Institutions
- Boston University (US)
- Western Cape Department of Health (ZA)
- Johns Hopkins University (US)
- University of the Witwatersrand (ZA)
- Vanderbilt University (US)
- Johns Hopkins Medicine (US)
- Ohio Department of Health (US)
- London School of Hygiene & Tropical Medicine (GB)
- National Institute for Public Health and the Environment (NL)
- Centro de Investigación Biomédica en Red (ES)
- Manhiça Health Research Centre (MZ)
- Aurum Institute (ZA)
- Amsterdam Institute for Global Health and Development (NL)
- Africa Health Research Institute (ZA)
- Barcelona Institute for Global Health (ES)
- Perinatal HIV Research Unit (ZA)
- The Ohio State University (US)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2026-03-17
- DOI
- https://doi.org/10.1093/infdis/jiag165
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00