Does Platelet-Rich Plasma Speed Recovery After Acute Lateral Ankle Sprain? A Prospective Comparative Study Among Athletes

Leukocyte-poor PRP did not improve PROMIS Pain Interference, PROMIS Physical Function, or overall return to sport rates compared with conventional care. Although a statistically significant and clinically meaningful acceleration in time to return to sport with a moderate effect size was observed, this outcome was exploratory and underpowered, and larger prospective trials are required for confirmation.