Development and internal validation of a risk stratification scoring system for identifying gram-negative ESBL-positive acute cholangitis: A retrospective cohort study
This preliminary scoring system demonstrated high specificity at higher cutoffs, supporting its use as a rule-in tool for identifying patients at high risk of ESBL-producing bacteria in acute cholangitis. However, its moderate sensitivity limits its role as a rule-out strategy. This preliminary internally validated model should not be used to guide routine clinical decision-making without external multicenter validation, and any application must consider local resistance patterns and patient context.
Authors
- Thanawin Wong (ORCID: https://orcid.org/0000-0003-2868-841X)
- Jaksin Sottisuporn (ORCID: https://orcid.org/0000-0002-6254-2759)
- Nisa Netinatsunton (ORCID: https://orcid.org/0000-0002-3351-6252)
- Tanawat Pattarapuntakul (ORCID: https://orcid.org/0000-0002-6582-9608)
- Phoomjai Sornsenee (ORCID: https://orcid.org/0000-0001-6992-033X)
- Chanchanok Chaochuensuk
- Duangkiat Sapsong
- Phirada Khongrueang
- Panitsara Raksorn
- Suppachai Choengdee
- Suphajit Nuypud
- Kanyakorn Khongchuy
- Paisit Kangton
- Teerapob Wetchasit
- Thanet Oonthae
Institutions
- Prince of Songkla University (TH)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-03-17
- DOI
- https://doi.org/10.1371/journal.pone.0345150
- Primary Topic
- Gallbladder and Bile Duct Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00