Cord blood transfusion added matched unrelated donor transplantation as a preferable choice for aplastic anaemia: a comparative study from a single centre
MUD-cord-HSCT provides an optimal solution for MC and GVHD, with outcome comparable or even better than those of MSD-HSCT.KEY MESSAGESThe best choice of alternative donor for aplastic anaemia remains a clinical challenge, unrelated donors (URDs) or haploidentical (Haplo) donor?Umbilical cord blood (UCB) transfusion added matched unrelated donor (MUD) haematopoietic stem cell transplantation (HSCT) exert nearly 0% cumulative incidence of mixed chimerism and grade II-IV acute/chronic GVHD;UCB added MUD-HSCT (MUD-cord-HSCT), which exert 100% three-year overall survival (OS) and 85.7% event free survival (EFS), rather than matched sibling donor (MSD)-HSCT, exert superiority in OS and EFS than mismatched URD (MMUD)-HSCT and haploidentical-HSCT.MUD-cord-HSCT provides an optimal solution for MC and GVHD, with outcome comparable or even better than those of MSD-HSCT.
Authors
- Yaonan Hong (ORCID: https://orcid.org/0000-0003-1146-0072)
- Dijiong Wu
- S. Qiu Liu
- Q. Liu
- Xinru Jia (ORCID: https://orcid.org/0000-0002-0174-1543)
- Wei Liu (ORCID: https://orcid.org/0009-0000-2359-1331)
- Qinghong Yu (ORCID: https://orcid.org/0000-0002-7326-7609)
- Xiaojun Yang (ORCID: https://orcid.org/0000-0001-9082-4764)
- B. Ye
- Ye Shen (ORCID: https://orcid.org/0009-0000-1064-7885)
- Shengyun Lin
- Jianping Shen (ORCID: https://orcid.org/0000-0002-9999-7482)
- Zexing Sun
- Rudan Zheng
- Tonglin Hu
- Yuhong Zhou
- Chuanao Xin
Institutions
- Zhejiang Chinese Medical University (CN)
- Wenzhou Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1080/07853890.2026.2635832
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00