Potential Risks of Blocking <scp>GDF15</scp> ‐Based Brain Energy Sensing

GDF15 signals energetic stress to the brain, leading to unpleasant symptoms as the body conserves and reallocates energy. In conditions such as frailty and cancer, suppression of GDF15 signaling is expected to lead to an improvement in symptoms, but potentially at the cost of long-term health and survival.

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Publication Details

Journal
Journal of the American Geriatrics Society
Published
2026-03-16
DOI
https://doi.org/10.1111/jgs.70399
Primary Topic
GDF15 and Related Biomarkers
Type
article
Field-Weighted Citation Impact
0.00
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article

Potential Risks of Blocking GDF15 ‐Based Brain Energy Sensing

Adi Cohen, Martin Picard
Journal of the American Geriatrics Society
GDF15 and Related Biomarkers
article

Potential Risks of Blocking GDF15 ‐Based Brain Energy Sensing

Adi Cohen, Martin Picard
article en

Abstract

GDF15 signals energetic stress to the brain, leading to unpleasant symptoms as the body conserves and reallocates energy. In conditions such as frailty and cancer, suppression of GDF15 signaling is expected to lead to an improvement in symptoms, but potentially at the cost of long-term health and survival.

Journal of the American Geriatrics Society
Columbia University Irving Medical Center (US), Columbia University (US)
Affordable and clean energy
Openalex Percentile: Top 19%
GDF15 and Related Biomarkers
DOISourceOpenAlex
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Potential Risks of Blocking <scp>GDF15</scp> ‐Based Brain Energy Sensing — Adi Cohen, Martin Picard · Journal of the American Geriatrics Society (2026) | TGRS Research Map | TGRS