571eTiP Prospective evaluation of body composition in patients with non-small cell lung cancer treated with tyrosine-kinase inhibitors (BOLT study)

was proposed to 167 pts (52%), of whom 13 (4%) were referred to/from other centres.Overall, 154 pts (47.5%) were then enrolled in CT, including observational (72%), interventional (16%) and expanded access programmes (1.3%).Among pts enrolled in CT, 32% were female, 51% were married and 54% had children.54% had a caregiver.Most enrolling oncologists were younger than 45 years, had 10-19 years of experience, worked in research cancer centres and reported fewer than 20 daily pts visits.Reasons for not-considering CT are detailed in the table.Table: 569eP Reasons for not considering CT N of pts (%) Screening failure 7 (2) No trial in those centres 48 (15) No trial in national territory 23 (7) Unsatisfied inclusion/exclusion criteria 38 (11) Patient reluctance 7 (2) Conclusions: ENGAGE is an ongoing multicentre trial providing real-world insights into factors influencing CT enrolment in LC.Preliminary results show a persistent gender imbalance, underscoring the need for strategies to ensure equitable access to clinical research.Clinical trial identification: Protocolv.3.0, released on 30/04/2024.