Non-canonical peptidoglycan cross-linking is essential for <i>Mycobacterium tuberculosis</i> acid resistance

Disabling a key peptidoglycan cross-linking enzyme compromises <i>M. tuberculosis</i> survival under acidic stress and antibiotic exposure.

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Publication Details

Journal
bioRxiv (Cold Spring Harbor Laboratory)
Published
2026-03-16
DOI
https://doi.org/10.64898/2026.03.16.712108
Primary Topic
Tuberculosis Research and Epidemiology
Type
article
Field-Weighted Citation Impact
0.00
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article

Non-canonical peptidoglycan cross-linking is essential for Mycobacterium tuberculosis acid resistance

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bioRxiv (Cold Spring Harbor Laboratory)
Tuberculosis Research and Epidemiology
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Non-canonical peptidoglycan cross-linking is essential for Mycobacterium tuberculosis acid resistance

Ruoyao Ma, Alexandre Gouzy, Karl L. Ocius, Dilia Rea, Ananya Naick, Claire Healy, Marcos Pires, Sabine Ehrt, felipe Cava, Thomas Ioerger
article en

Abstract

Disabling a key peptidoglycan cross-linking enzyme compromises <i>M. tuberculosis</i> survival under acidic stress and antibiotic exposure.

bioRxiv (Cold Spring Harbor Laboratory)
University College Dublin (IE), Trinity College Dublin (IE), Cornell University (US), Science for Life Laboratory (SE), University of Virginia (US), Umeå University (SE), Texas A&M University (US)
Openalex Percentile: Top 20%
Tuberculosis Research and Epidemiology
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