317P A phase II clinical study of neoadjuvant immunogenic radiotherapy followed by ivonescimab (PD-1/VEGF-A bispecific antibody) and chemotherapy in stage II-III non-small cell lung cancer

In recent years, neoadjuvant immunotherapy combined with chemotherapy has been increasingly applied in resectable non-small cell lung cancer (NSCLC). An improved pathological response correlates with survival benefit. This study is to evaluate the efficacy and safety of combining immunomodulatory radiotherapy with ivonescimab and chemotherapy in stage II–III NSCLC.

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Publication Details

Journal
ESMO Open
Published
2026-03-17
DOI
https://doi.org/10.1016/j.esmoop.2026.106627
Primary Topic
Cancer Immunotherapy and Biomarkers
Type
article
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article

317P A phase II clinical study of neoadjuvant immunogenic radiotherapy followed by ivonescimab (PD-1/VEGF-A bispecific antibody) and chemotherapy in stage II-III non-small cell lung cancer

L. Zhang, B. Liu, F. Chen, X. Lv et al.
ESMO Open
Cancer Immunotherapy and Biomarkers
article

317P A phase II clinical study of neoadjuvant immunogenic radiotherapy followed by ivonescimab (PD-1/VEGF-A bispecific antibody) and chemotherapy in stage II-III non-small cell lung cancer

L. Zhang, B. Liu, F. Chen, X. Lv, L. Wang, M. Shi, S. Su, Z. Liu, R. Yang
article en

Abstract

In recent years, neoadjuvant immunotherapy combined with chemotherapy has been increasingly applied in resectable non-small cell lung cancer (NSCLC). An improved pathological response correlates with survival benefit. This study is to evaluate the efficacy and safety of combining immunomodulatory radiotherapy with ivonescimab and chemotherapy in stage II–III NSCLC.

ESMO OpenVol. 11
Nanjing Drum Tower Hospital (CN)
Good health and well-being
Openalex Percentile: Top 19%
Cancer Immunotherapy and Biomarkers
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