Role of <i>BARX1</i> in Development and Disease

Homeobox genes encode diverse proteins, including proteins with highly conserved DNA-binding domains, and are essential for organismal growth, cell differentiation, organ development, and diverse physiological processes associated with diseases. BARX1 encodes a transcription factor containing the BarH1-like homeodomain. This gene plays a significant role in the development of various tissues and is closely associated with the pathogenesis and progression of numerous diseases. In this review, we provide a comprehensive overview of the functional networks and mechanisms of action of the BARX1 gene across different tissue developmental processes and disease contexts.