Interleukin 11–Induced MicroRNAs as Functional Mediators and Circulating Biomarkers of Cardiac Fibrosis
In this study, we have newly identified the potential value of microRNA-27b-5p and microRNA-497-5p as actionable biomarkers of the profibrotic response to IL-11 in the heart. Future studies should validate the translational potential of the microRNAs as new clinical biomarkers and therapeutic targets.
Authors
- Lorenzo Menicanti (ORCID: https://orcid.org/0000-0001-8530-6284)
- Germana Zaccagnini (ORCID: https://orcid.org/0000-0002-9441-4735)
- Zoe Kwan
- Carla Lucarelli (ORCID: https://orcid.org/0000-0002-5321-1149)
- Simona Greco (ORCID: https://orcid.org/0000-0002-0275-7221)
- Chi Him Kendrick Yiu (ORCID: https://orcid.org/0000-0001-8070-972X)
- Mark Sweeney
- Catherine Mansfield (ORCID: https://orcid.org/0000-0002-5063-5181)
- Julia Gorelik (ORCID: https://orcid.org/0000-0003-1148-9158)
- Santiago Nicolas Piella
- Julia Dielesen
- Prashant K. Srivastava (ORCID: https://orcid.org/0000-0003-1454-5493)
- Maddalena Tessari
- Giuseppe Faggian (ORCID: https://orcid.org/0000-0001-5371-5761)
- Joseph Okafor (ORCID: https://orcid.org/0000-0002-1021-6134)
- Giovanni Battista Luciani (ORCID: https://orcid.org/0000-0003-0931-018X)
- Roman Tikhomirov (ORCID: https://orcid.org/0009-0001-7831-8073)
- Maryam Anwar (ORCID: https://orcid.org/0000-0002-0545-8403)
- Veronika Boichenko
- Victoria Maria Noakes
- Costanza Emanueli
- P Leszek
- Diana Kazharova
- Mathilde Labbé
- Fabio Martelli
- Benedict Reilly O’Donnell
Institutions
- University of Verona (IT)
- Imperial College Healthcare NHS Trust (GB)
- IRCCS Policlinico San Donato (IT)
- Lung Institute (US)
- MRC London Institute of Medical Sciences (GB)
- Imperial College London (GB)
- Cardinal Stefan Wyszynski University in Warsaw (PL)
Publication Details
- Journal
- Circulation Research
- Published
- 2026-03-17
- DOI
- https://doi.org/10.1161/circresaha.125.326799
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00