Distinct hepcidin patterns in Crohn’s disease and ulcerative colitis: links to iron homeostasis and inflammatory activity
Ferritin showed the strongest association with hepcidin across IBD, but regulation differed by disease. In UC, lower hepcidin levels were associated with intestinal inflammatory activity measured by fecal calprotectin, whereas in CD, higher hepcidin levels were associated with systemic inflammation despite iron deficiency. These findings highlight hepcidin's potential as a biomarker linking iron status and inflammatory type in IBD.
Authors
- Jorge Amil Dias (ORCID: https://orcid.org/0000-0003-2704-4508)
- Beatriz Domingues (ORCID: https://orcid.org/0000-0002-6353-7775)
- Joana Roseira (ORCID: https://orcid.org/0000-0002-5098-8729)
- Raquel Gusmão Oliveira (ORCID: https://orcid.org/0000-0002-9130-6800)
- Helena Tavares de Sousa (ORCID: https://orcid.org/0000-0002-6626-205X)
- Rita Melo-Miranda (ORCID: https://orcid.org/0000-0001-7845-5767)
- Francisco Portela
- F Magro
- P Ministro
- M Santiago
- Samuel Fernandes
- Sandra Dias
- Ricardo Crespo
Institutions
- Universidade do Porto (PT)
- Hospital de São João (PT)
- Escola Superior de Tecnologia da Saúde de Coimbra (PT)
- Instituto Português de Oncologia Francisco Gentil (PT)
- Administração Regional de Saúde de Lisboa e Vale do Tejo (PT)
- Algarve Biomedical Center (PT)
- Centre for Health Technology and Services Research (PT)
- Hospital de Santa Maria (PT)
- University of Algarve (PT)
Publication Details
- Journal
- Journal of Crohn s and Colitis
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1093/ecco-jcc/jjag023
- Primary Topic
- Iron Metabolism and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00